Ovid Technologies Field Guide

MEDLINE® (MEDL)


2003 Reload News!

Scope | General Information | Searching Fields | Limits
Stopwords | Changing to this Database From Another Database
Sample Documents | Copyright Information | Updated

Scope

MEDLINE is the U.S. National Library of Medicine's (NLM) premier bibliographic database covering the fields of medicine, nursing, dentistry, veterinary medicine, the health care system, and the preclinical sciences. MEDLINE contains bibliographic citations and author abstracts from more than 4,600 biomedical journals published in the United States and 70 other countries. The file contains over 11 million citations dating back to the mid-1960's, including approximately 130,000 population-related journal citations unique to the former POPLINEŽ database, added to MEDLINE in October of 2002. Coverage is worldwide, but most records are from English-language sources or have English abstracts. Abstracts are included for about 52% of the records.


General Information

Producer
National Library of Medicine
MEDLARS Management Section
8600 Rockville Pike
Bethesda, MD 20894
Phone: (888) FIND-NLM (888.346.3656)
Website: http://www.nlm.nih.gov
Years of Coverage
Note: Each segment can be searched individually or in combination using the use command. e.g. use medl or use med2,med3
For Ovid Online and Most Local Installations:
MESX: MEDLINE Daily Update (rolling monthly file)
MEDC: 1966-2003 (corrections only)
MESZ: 1966 - Present
MEDF: 1996 - Present
MEDL: 2003 - Present
MED7: 2001-2002
MED6: 1999-2000
MED5: 1996-1998
MED4: 1993-1995
MED3: 1989-1992
MED2: 1982-1988
MED1: 1966-1981
Default Fields for Unqualified Searches (searches as .mp.)
TI, AB, RW, SH
All Display/Print Fields
UI, MI, RO, AU, IN, TI, OT, SO, AS, LM, SH, KW, AB, OA, RN, PT, LG, CM, GS, MS, NO, NT, CP, PN, SM, SB, JC, IS, EP, ED, RD, UP
Default Save/Print Fields
UI, MI, RO, AU, IN, TI, OT, SO, SH, KW, AB, OA, RN
Default Display Fields
UI, MI, RO, AU, IN, TI, OT, SO, SH, KW, AB, OA, RN, CM
Elements of SO (Source) Field
JN, PB, VO, IP, PG, YR
Online Update Frequency
daily and weekly
Local Update Frequency
weekly, monthly
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Searching the MEDLINE Fields

The following alphabetical list provides the two letter label, the relevant alias, and at least one example for all searchable MEDLINE fields.
=====   ============ 
Label   Name/Example 
=====   ============ 


AB	Abstract [Word Indexed]
	bone density.ab. 
	drug abuse.ab. 

The abstract index contains all searchable words from the abstract.

Since 1975, MEDLINE has included author-written abstracts from journals whose publishers gave the 
NLM permission for their use. These abstracts appear in the Abstract (AB) field. Over 50% of the 
documents in MEDLINE contain abstracts.

Stopwords, such as "the" and "of" are not searchable.
 
AF	All Searchable Fields
	whitman walker.af.
	gmhc.af. 

All Fields (AF) is an alias for all of the fields which occur in the source 
documents, including value-added fields such as Subject Headings. The only thing 
excluded from an All Fields search are fields such as "floating subheading" or 
"heading word" which are created by the loading process and do not actually 
appear in the record. 


AU	Authors [Phrase Indexed]
 	rise j.au.
 	smith $.au. 

The Author (AU) field contains the authors of the article. The format for authors 
is last name followed by one or more initials: Smith JC or Smith J.

Enter the last name, or if it is a common name, enter the last name and first initial. 
If you are unsure of the spelling of the last name (macdonald or mcdonald), enter one 
version and then scroll through the list of names to find the other.


CM	Comments [Word Indexed] 
	jama.cm.

The Comments (CM) field contains an indication that the article either contains a 
comment on another article or is commented on in another article.  The Comment 
field begins with the indication "Comment On" or "Comment In" and then displays 
a journal abbreviation, volume/issue/date and pagination.


CP	Country of Publication [Phrase Indexed]
 	france.cp.
 	united states.cp. 

The Country of Publication (CP) field contains the full name of the country in which an 
article was published. The country name is entered into the index as a phrase.

 

ED	Entry Date [Phrase Indexed]
 	20011215.ed.
 	20000929.ed. 

The Entry Date (ED) field contains the issue (year, month and day) in which the document 
was indexes as a completed Medline record. This index appears in the format YYYYMMDD. 


EP	Electronic Date of Publication [Phrase Indexed]
 	20011215.ep.
 	 
The Electronic Date of Publication (EP) is the date the record or article was 
sent to NLM for inclusion in MEDLINE. It displays in the YYYYMMDD format. 


FS	Floating Subheading [Phrase Indexed]
 	et.fs.
 	di.fs. 

The Floating Subheadings (FS) field contains the 2-letter codes,
such as "po" for poisoning, and is displayed following the corresponding 
MeSH Subject Headings.

Subheadings are qualifiers added to MeSH subject headings to refine their meaning.  
Terms such as "etiology" or "therapy", when combined with a MeSH heading, give a
very precise idea of what an article covers.


GS 	Gene Symbol [Phrase Indexed]
 	agr.gs.
 	ela.gs. 

The Gene Symbol (GS) field contains Gene Symbols as they are entered into MEDLINE in 
the original document. They often, but not always, conform to standardized human gene 
nomenclature. Ignore super or sub-scripts in entry of a gene symbol: psub 1450 would be 
entered p1450. Enter hyphens as in the original symbol.

The Gene Symbol field was added to MEDLINE in 1991. Beginning in 1996, data will no 
longer be added to this field.


GW 	Gene Symbol Word [Word Indexed]
 	cd4.gw.
 	mada.gw. 

The Gene Word (GW) field contains individual words from the Gene Symbol (GS) field.
The Gene Symbol field was added to MEDLINE in 1991. Beginning in 1996, data will no 
longer be added to this field.
 
 

HW, ME 	Subject Heading Word [Word Indexed]
 	diazepam.hw.
 	blood.hw. 

The Subject Heading Word (HW) field allows you to retrieve every MeSH subject heading 
that includes a particular word. Do this by searching a single word in HW.



IA	Investigator Affiliation [Word Indexed]
	university.ia.

The Investigator Affiliation (IA) field contains the affiliation of the 
investigator of the article, and displays as part of the Institution (IN) 
field.
 

IN	Institution [Word Indexed]
 	harvard.in.
 	case western.in. 

The Institution (IN) field contains the primary author's affiliation, which 
is usually the source for a reprint of the article. This index also contains 
the investigators affiliation. This information can be searched in most documents 
since 1988, but records from earlier years which were added to the database 
after 1988 may also contain institution information. Beginning with documents 
indexed in 1996, the primary author's email address will also be included, 
if present in the journal.

The information is taken from the source document and is not standardized. Enter 
the single most descriptive word in an institution (harvard, not university). 
Consider both full spellings and abbreviations.


IP 	Issue/Part [Word Indexed]
 	"3".ip.
 	"45".ip. 

The Issue/part field (IP) contains the Issue and/or part for a particular volume 
of a journal. The IP field usually displays as part of the Source (SO) field. 



IR	Investigator [Phrase Indexed]
	young lr.ir.  
	zile mr.ir.

The Investigator (IR) field contains the investigators of the article. The format 
for authors is last name followed by one or more initials: Smith JC or Smith J.

Enter the last name, or if it is a common name, enter the last name and first initial. 
If you are unsure of the spelling of the last name (macdonald or mcdonald), enter one 
version and then scroll through the list of names to find the other.
 



IS 	ISSN/ISBN Number [Phrase Indexed]
 	0098 7484.is.
 	8756 971X.is. 

The ISSN (IS) field contains the International Standard Serial Number (ISSN) for the 
journal in which an article was published.

It appears as an 8 digit number, separated by a hyphen: 0028-4793.

JC 	NLM Journal Code [Phrase Indexed]
 	0004047.jc.
 	9892185.jc. 

The NLM Journal Code (JC) is an alpha-numeric code established by NLM which uniquely 
identifies every journal indexed in the NLM databases. Only the 7 digit code is 
searchable, in some cases the 3 digit alpha-numeric code will display as well.


JN, JT 	Journal Name [Phrase Indexed]
 	archives of dermatology.jn.
 	jama.jn. 

The Journal Name (JN) field contains the full name of the journal in which the article 
was published. Journal names are indexed as phrases, so enter enough letters of the 
journal name to locate the name in the index: new engl (for New England Journal of Medicine).

Stopwords such as "of" ARE included in the JN index, but when "the" is the first word of 
a journal, it has been stripped.


JW 	Journal Word [Word Indexed]
 	obstetrics.jw.
 	psychology.jw. 

The Journal Word (JW) field contains individual words from every journal name in MEDLINE.
Stopwords such as "the" or "of" are not included. This field is used to retrieve every 
occurrence of a journal which includes a particular word, such as "obstetrics".


KF 	Keyword Heading Word [Word Indexed]
	nature.kf.

Sometimes you may wish to retrieve every Keyword Heading that includes a 
particular word; this is done by searching the single word in the Keyword 
Heading Word (KF) field.


KW	Keyword Heading [Phrase Indexed]
	utilitarianism.kw.

The Keyword Heading (KW) field contains the Keyword Headings assigned by 
indexers at NLM to describe the content of an article. If you may want 
to retrieve every Keyword Heading that includes a particular word; this is done 
by searching the single word in the Keyword Heading Word (KF) field. 

LG, LA	Language [Phrase Indexed]
 	fre.lg.
 	eng.lg. 

The Language (LG) field contains the language(s) of publication of an article. 
The language name will appear in the index as a 3-letter code (such as fre for 
French); the codes are usually, but not always, the first three letters of the 
language name. The language index is quickly scrollable to determine all 
languages which appear in MEDLINE.

MI	MEDLINE Identifier [Phrase Indexed]
	20003508.mi.
	99441106.mi.

The MEDLINE Identifier (MI) field contains the NLM Class Maintenance number. 
This number was formally the Unique Identifier (UI). 


MS 	Molecular Sequence [Phrase Indexed]
 	swissprot-s33667.ms.
 	swissprot-z8200.ms. 

The Molecular Sequence (MS) field contains an organizational acronym and the 
unique identifier that organization has applied to a molecular sequence.

The acronym appears first followed by a hyphen and the unique identifier: 
genbank-x55010.

The Molecular Sequence (MS) field was added to MEDLINE in 1988.


NO	Grant Number [Phrase Indexed]
 	Zr01ai28076.no.
 	Zr25ca571206.no. 

The Grant Numbers (NO) field was created by NLM in 1981 to specify documents 
reporting on federally-funded research.

Grant or contract numbers are displayed in full, but special characters 
except hyphens have been removed from the index.


NT	General Note [Display Only]

The General Note (NT) field contains either a series name and number or
general supplementary information about an item.  The notes may include 
information on the availability of a bibliography, ordering information 
for dissertations or hearings, or general summaries of materials such as 
manuals or scripts.  A series title may appear for a book or for 
audiovisual materials.


OA	Other Abstract [Word Indexed]
	crime.oa.

The Other Abstract (OA) field includes a brief abstract written by staff 
members of the Kennedy Institute of Ethics.  The abstract index contains all 
searchable words from the abstract.


OT 	Original Title [Word Indexed]
 	coeur.ot.
 	no43gene.ot. 

The Original Title (OT) includes any non-English titles in the original 
language. If the original title was in a non-Roman alphabet, then the 
OT is transliterated. 
 

PB 	Publisher [Word Indexed]
 	ecol.pb.
 	hume.pb. 

The Publisher (PB) field contains publisher information for books, monographs 
or any non-journal publications. This information is taken from the source 
document as it appears, so variant forms of a publisher are possible. 

This field is usually displayed as part of the Source (S0) field. 


PG	Page [Phrase Indexed]
 	"44".pg.
 	"237".pg. 

The Page (PG) field is the first page on which an article appears. Often a journal 
title combined with the beginning page number is enough to locate 
a citation. This field is usually displayed as part of the Source (SO) field. 


PN 	Personal Name as Subject [Phrase Indexed]
 	monet c$.pn.
 	adams s$.pn. 

The Personal Name As Subject (PN) field displays the name of a well-known person 
if they are discussed in an article, such as an interview or obituary.

The format for Personal Name is the same as for Author -- last name and initials: 
Bach JS. Enter a last name and one initial if known.


PT 	Publication Type [Phrase Indexed]
 	bibliography.pt.
 	review.pt. 

The Publication Type (PT) field displays the terms the indexers at 
the National Library of Medicine assign terms to describe the article type. 

To view the index, enter enough letters to distinguish a publication type 
(jour for "journal article"); the entire index is quickly scrollable to determine 
all possible publication types.


RD	Revision Date [Phrase Indexed]
	20001218.rd.

The Revision Date (RD) field contains the issue (year, month and day) in which 
the document was revised in Index Medicus.  The RD field appears in the format
YYYYMMDD. Previously, the RD filed was indexed with the Entry Date (ED) field. 
Now, it is a separate index.


	RN, NM	CAS Registry Number / EC Number [Phrase Indexed]
 	38404-93-2-5.rn.
 	ec 1-1-1-101.rn. 

The CAS Registry/EC Number (RN) field contains the Chemical Abstracts Service 
Registry number or Enzyme Commission number for a compound mentioned in an article. 
If the generic compound name can be determined, it is included. The RN field was 
added to MEDLINE in 1980.

Registry numbers appear with hyphens (50-00-0); EC numbers appear in the format 
ec 1-1-1-3; and chemical names appear with all special characters except hyphens 
removed.
 

RO	Record Owner [Phrase Indexed]
	kie.ro.

The Record Owner (RO) field contains the owner of the record.

	ECRI = a non profit health services research agency based in Plymouth Meeting, PA
	HMD = History of Medicine Division, National Library of Medicine
	HSR = Health Services Research
	KIE = Kennedy Institute of Ethics, Georgetown University
	NASA = National Aeronautics and Space Administration
	NLM = National Library of Medicine
	PIP = Johns Hopkins University Center for Communication Programs
 	

RW 	CAS Registry Number / EC Number Word [Word Indexed]
	binding.rw.
	enzyme$.rw. 

The CAS Registry/EC Number Word (RW) field contains single words from the registry number 
field and is used to search portions of chemical names.

The CAS Registry/EC Number (RN) field was added to MEDLINE in 1980.
 

SB	Journal Subset [Phrase Indexed]

The Journal Subset (SB) field displays the division of subsets created in the MEDLINE database: 


	AIM = Abridged Index Medicus Journals
	B = Biotechnology Journals (assigned 1990-1998), non-Index Medicus
	C = Communication Disorders Journals (assigned 1977-1997), non-Index Medicus
	D = Dentistry Journals
	E = Bioethics Journals, non-Index Medicus
	H = Health Administration Journals, non-Index Medicus
	IM = Index Medicus Journals
	K = Consumer Health Journals, non-Index Medicus
	N = Nursing Journals
	Q = History of Medicine Journals, non-Index Medicus
	QO = Older History of Medicine Journals
	R = Reproduction Journals (assigned 1972-1979), non-Index Medicus
	S = National Aeronautics and Space Administration (NASA) Journals, non-Index Medicus
	T = Health Technology Assessment Journals, non-Index Medicus
	X = AIDS/HIV Journals, non-Index Medicus
 


SH, DE, CT, SW 	MeSH Subject Heading [Phrase Indexed]
 	ulcer.sh.
 	sarcoma kaposi.sh. 

The MeSH Subject Headings (SH) field contains the Medical Subject Headings used by 
indexers at NLM to describe the content of an article. NLM's MeSH terms are organized 
in a hierarchy, or "tree" structure.

MeSH headings are entered into the index as phrases and should be searched as 
they appear in the NLM MeSH books or in our Tree display.
 

SM	Space Flight Mission [Phrase Indexed]
	flight experiment.sm.
	galileo project.sm

The Space Flight Mission (SM) field provides descriptive values for each Space 
Flight Mission.


SO 	Source (JN, PB, PG, YR, VO, IP)
 	bioelectrochemistry.so.
 	tennessee medicine.so. 

The Source (SO) field includes a display of all the basic information needed to 
locate a citation, including the full Journal Name or Monograph Publisher, the 
Vol/Issue, pagination and year of publication. 


TI 	Title [Word Indexed]
 	bone.ti.
 	nursing care.ti. 

The Title (TI) field contains the English language version of a title. For documents 
which were not written in English, the original or transliterated title appears in a 
separate field, Original Title (OT).

Stopwords such as "of" or "the" will display in documents but do not appear in the 
Title index. However, the word "a", which is a stopword in other fields CAN be 
searched in titles.


TW	Text Word (AB, TI)
 	diazepam.tw.
 	squibb.tw. 

The Textword (TW) field is an alias for all of the fields in a database which contain 
text words and which are appropriate for a subject search.

The Textword field in MEDLINE includes Title (TI) and Abstract (AB).


UI, AN	Unique Identifier [Phrase Indexed]
	10885016.ui.
	10900377.ui. 
	10936459.ui.

The Unique Identifier (UI) field contains an 8-digit number assigned by MEDLINE 
to uniquely identify a particular record. This number is also the one used to 
locate the document through NLM's document delivery service. This number was 
formally the PubMed Identifier. 
 


UP	Update Date [Phrase Indexed]
 	20020107.up.

The Update Date (UP) field contains the date the record was added to 
Ovid's MEDLINE. The UP field appears in the format YYYYMMDD.


VO 	Volume [Word Indexed]
	"49".vo.
	"13".vo. 

The Volume (VO) field consists of the volume and issue of a serial 
publication. This field is usually displayed as part of the Source (SO) field. 



XM	Exploded MeSH Heading [Phrase Indexed]
	"dopamine agents*".xm.
	exocrine glands.xm. 

The Exploded MeSH Heading (XM) field displays pre-exploded MeSH Headings. MeSH 
Subject Headings are hierarchical, with up to twelve levels of narrower terms 
from the top of a hierarchy. In order to retrieve a term and all of its narrower 
terms, a subject heading must be "exploded", that is, the subject heading and all 
narrower terms are "OR'd" together. OVID pre-explodes highly-posted broader terms 
with their narrower terms during loading. 


XS 	Exploded Subheading [Phrase Indexed]
	ae.xs.
	di.xs. 

The Exploded Subheadings (XS) field displays the two-letter codes for the 
pre-exploded subheadings. 

Sometimes multiple MeSH Subheadings can be logically grouped
together.  Such related groups of subheadings are "pre-exploded"
under one broad subheading.  This means that all the grouped
subheadings can be retrieved together by searching on the "pre-exploded"
version of the broad subheading.



YR 	Year of Publication [Phrase Indexed]
	2001.yr. 

The Year of Publication (YR) field contains the year in which an article or 
monograph was published. Only the four digit years appear in the index. 

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MEDLINE Limits

The following limits are available from the Limit menu on the Main Search Page:

Popular Command and Sentence Syntax Limits:

	Abstracts
	Command Syntax:       ..l/ ab=y
	Sentence Syntax:      limit 1 to abstracts

	Age Groups
	Sentence Syntax:      limit 1 to infant
	                      limit 1 to adult

Note: A change has been made to the age limit. Because of the Age Group changes in the MeSH headling, the Adolescence limit is now Adolescent. The functionality is the same, therfore the limit will excute infant newborn.sh. or infant.sh. or child preschool.sh. or child.sh. or adolescent.sh.

Middle Aged <45 plus years of aged> Sentence Syntax: limit 1 to middle aged Animal/Human Command Syntax: ..l/1 hu=y Sentence Syntax: limit 1 to human limit 1 to animal Animal Types Sentence Syntax: limit 1 to cats limit 1 to rabbits English Language Command Syntax: ..l/1 en=y Sentence Syntax: limit 1 to english Journal Subsets Command Syntax: ..l/1 sb=aim Sentence Syntax: limit 1 to aim journals Languages Command Syntax: ..l/1 lg=fre Sentence Syntax: limit 1 to french Female/Male Sentence Syntax: limit 1 to female limit 1 to male Publication Types Sentence Syntax: limit 1 to journal article limit 1 to clinical trial limit 1 to review Publication Years Command Syntax: ..l/1 yr=1996 Sentence Syntax: limit 1 to yr=1996

There are range limits for both the RD and ED fields. These limits are not listed in the pulldown, however they can be used from the command line. To run the limits use the following syntax from the command line.

	limit 1 to ed=20021001-20021115

	limit 1 to rd=20021001-20021115
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MEDLINE Stopwords

Words of little intrinsic meaning that occur too frequently to be useful in searching text are known as "stopwords." You cannot search for the following stopwords by themselves, but you can include them within phrases.

a by having neither seem those
about can how no seen through
after could however nor several thus
again did if not should to
all do in obtain show under
almost does into obtained showed up
also done is of shown upon
although during it often shows use
always each its on significant used
among either itself only significantly using
an enough just or since various
and especially kg other so very
another etc km our some was
any followed largely out such we
approximately following like overall suggest were
are for made per than what
as found mainly perhaps that when
at from make possible the whereas
be further may previously their which
because give might quite theirs while
been given min rather them with
before giving mm really then within
being had most regarding there would
between hardly mostly resulted these  
both has must resulting they  
but have nearly same this  
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Change to MEDLINE From Another Database

Search Labels:
    For Ovid Online and Most Local Installations:    
MESX: MEDLINE Daily Update (rolling monthly file)
MEDC: 1966-2002 (corrections only)
MESZ: 1966 - Present
MEDF: 1996 - Present
MEDL: 2002 - Present
MED7: 2000-2001
MED6: 1998-1999
MED5: 1996-1997
MED4: 1993-1995
MED3: 1989-1992
MED2: 1982-1988
MED1: 1966-1981

Examples:

	use medl
	..c/medl

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Sample MEDLINE Documents

<1>
Unique Identifier
10528460
Medline Identifier
99457767
Record Owner
NLM
Authors
Catlin AJ. Stevenson DK.
Institution
Napa Valley College, CA, USA. acatlin@napanet.net
Title
Physicians' neonatal resuscitation of extremely low-birth-weight preterm infants.[comment].
Comments
Comment in: J Nurs Scholarsh. 2000;32(2):114; PMID: 10887702, Comment in: J Nurs Scholarsh. 2000;32(2):114; PMID: 10887701
Source
Image - the Journal of Nursing Scholarship. 31(3):269-75, 1999.
Abbreviated Source
Image J Nurs Sch. 31(3):269-75, 1999.
NLM Journal Code
gg1, 8400753, 8400753
Journal Subset
IM, N
Country of Publication
United States
MeSH Subject Headings
Decision Making
Ethics, Medical
Human
Infant, Newborn
*Infant, Premature
*Infant, Very Low Birth Weight
*Physician's Practice Patterns
*Resuscitation
Support, Non-U.S. Gov't
United States
Abstract
PURPOSE: To examine the perceptions of physicians who make delivery room decisions to resuscitate extremely low-birth-weight 
(ELBW) neonates at marginal viability. Nurses, parents, economists, and ethicists have questioned resuscitation of ELBW 
neonates, many of whom experience high levels of morbidity and mortality. Yet no systematic studies were found that addressed 
physicians' perceptions and delivery room decisions. DESIGN: Descriptive, using naturalistic inquiry. A national U.S. 
convenience sample was obtained in 1996-1997 of 54 physicians in five perinatal subspecialties who resuscitated ELBW 
neonates. METHODS: Tape-recorded and transcribed interviews were analyzed using NUD*IST software and line-by-line 
constant comparison. FINDINGS: Despite awareness of the high morbidity and mortality, 96% of the physicians offered 
resuscitation to all ELBW neonates in the delivery room. The main factors affecting their decisions were "the role of 
physician;" having been "trained to save lives;" the belief that "if called, I resuscitate;" the inability to determine 
gestational age; requests from parents to "do everything;" and the need to move from a "chaotic" delivery room to a controlled 
neonatal intensive care unit. Six major themes were: role expectation, uncertainty, awareness, internal and external forces, 
burden, and continuing quandaries. Physicians were burdened by the devastated and dying babies, by their inability to predict 
which neonates had a chance for intact survival, and by conflicts with colleagues about viability. Statistical probability of 
survival, legal constraints, and cost of care did not appear to affect greatly their decisions. Physicians asked that society 
and national policy makers set parameters for resuscitation. CONCLUSIONS: The American Academy of Pediatrics' Neonatal 
Resuscitation Protocol needs revision to delineate the ethical criteria for resuscitation. Early prenatal education for 
families which clearly teaches the margins of viability and outcomes of early deliveries is also recommended. Physicians must 
be supported in changing the recessitation paradigm.
ISSN
0743-5150
Publication Type
Journal Article.
Language
English
Entry Date
19991104
Revision Date
20021211
Update Date
20021212


<2>
Unique Identifier
12383635
Medline Identifier
22272951
Record Owner
NLM
Authors
Zimmer GM. Wentink GH. Bruschke C. Westenbrink FJ. Brinkhof J. de Goey I.
Institution
Bomela 18, 5301 NL Zaltbommel, The Netherlands.
Title
Failure of foetal protection after vaccination against an experimental infection with bovine virus diarrhea virus.
Source
Veterinary Microbiology. 89(4):255-65, 2002 Nov 6.
Abbreviated Source
Vet Microbiol. 89(4):255-65, 2002 Nov 6.
NLM Journal Code
xbw, 7705469
Journal Subset
IM
Country of Publication
Netherlands
MeSH Subject Headings
Animal
Animals, Newborn
Antibodies, Viral / bl [Blood]
*Bovine Virus Diarrhea-Mucosal Disease / im [Immunology]
Bovine Virus Diarrhea-Mucosal Disease / pc [Prevention & Control]
Bovine Virus Diarrhea-Mucosal Disease / vi [Virology]
Carrier State / ve [Veterinary]
Cattle
*Diarrhea Viruses, Bovine Viral / im [Immunology]
*Disease Transmission, Vertical / ve [Veterinary]
Female
*Fetus / im [Immunology]
Fetus / vi [Virology]
Leukocyte Count / ve [Veterinary]
Netherlands
Random Allocation
Trachea / vi [Virology]
*Vaccination / ve [Veterinary]
Vaccines, Inactivated / im [Immunology]
Vaccines, Inactivated / st [Standards]
*Viral Vaccines / im [Immunology]
Abstract
A protocol is described to measure the protection of the bovine fetus against an experimental bovine virus diarrhea 
virus (BVDV) infection after vaccination. Two inactivated experimental vaccines were applied twice with a 3 week interval. 
A mixture of three different Dutch field strains was used as challenge on mainly the 82nd day of gestation to vaccinated 
and unvaccinated control animals. The challenge was applied 5 months after completion of the two-fold vaccinations. All 
calves born from unvaccinated control animals were persistently infected. The calves born from dams vaccinated with the 
two different inactivated BVDV vaccines were persistently infected in 78 and 60%, respectively.
CAS Registry/EC Number
0 (Antibodies, Viral). 0 (Vaccines, Inactivated). 0 (Viral Vaccines).
ISSN
0378-1135
Publication Type
Journal Article.
Language
English
Entry Date
20021211
Update Date
20021212.
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MEDLINE Producer Copyright Information

NLM represents that the data provided within MEDLINE is formulated with a reasonable standard of care. Except for this representation, and as otherwise specifically provided herein, NLM makes no representations or warranties, expressed or implied. This includes but is not limited to, any implied warranty of merchantability or fitness for a particular purpose, with respect to the NLM databases, and NLM specifically disclaims any such warranties and representations. Downloading data is permitted for personal use only. Some material in the NLM databases is from copyrighted publications of the respective copyright claimants. Users of the NLM databases are solely responsible for compliance with any copyright restrictions and are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publications, all of which are hereby incorporated by reference.

The following use of data from MEDLINE, AIDSLINE, BIOETHICSLINE and HEALTHSTAR requires no written permission from or signed licence agreement with NLM:

Users may download small amounts of data, e.g., the bibliographic citation and MeSH terms, for a small number of citations from the databases listed above for redistribution either via a printed publication or in electronic form using the Internet, World Wide Web, etc. Downloading from a MEDLARS licensee, such as OVID is subject to the licensee's approval.

Definitions:

1. Download includes ftping results of an online search, arranging for the results of an automatic stored search to be available for ftp, ftping MEDLARS data from the NLM server (nlmpubs.nlm.nih.gov), or a traditional download using a modem.

2. Small is defined as approximately 1,000 records per month from MEDLINE; 12,000 per year. Retrospective pulls of MEDLINE may include up to approximately 12,000 records for each year covered. For other MEDLARS databases, fewer than 25% of records in the file may be downloaded. For larger portions of a MEDLARS database, contact Janer@nlm.nih.gov or 301-496-7706 for licensing information.

3. Data is defined as bibliographic citations and MeSH terms. This document grants permission to download only the bibliographic citations and MeSH terms, it does not cover author abstracts from the journals which are included in MEDLINE and other MEDLARS databases. Users should obtain an opinion from their legal counsel for any use they plan for the author-generated abstracts in the MEDLARS database.

Terms and Conditions:

Users must ensure that all downloaded publicly accessable data stored in electronic form for over one year must be in compliance with the following provisions of the NLM license agreement:

A. Users of this data must be provided a clear description of how the product/service was derived, indicating the currency and the source database.

B. At least annually, the data downloaded must be corrected to incorporate the corrections NLM has made to these records during the year and in year end maintenance. MEDLARS data in any subsequently produced product/service must be carefully checked with that maintained on NLM's version of the database at the end of each calender year and corrections made.

C. Users are advised to consult legal counsel to ensure compliance with intellectual property laws. NLM cannot provide advice about copyright issues.

D. Since NLM goes to considerable efforts to assign MeSH terms, it prefers that these be retained as assigned by the indexers.

E. All downloaded NLM records (or portions thereof) must be labeled so as to identify NLM as the source.

F. Trademark symbols must properly be used when referring to the NLM databases, system and products. A product/service using downloaded data must be named in a fashion that clearly distinguishes it from NLM-produced databases accessible at NLM.


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Field guide last updated 20 December 2002